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Image Search Results
Journal: The American Journal of Pathology
Article Title: New Therapeutic Approach to Suppress Castration-Resistant Prostate Cancer Using ASC-J9 via Targeting Androgen Receptor in Selective Prostate Cells
doi: 10.1016/j.ajpath.2012.10.029
Figure Lengend Snippet: In vivo therapeutic and chemopreventive effects of ASC-J9 in genetically engineered mouse PCa models. A: Early treatment with ASC-J9 suppressed tumor initiation/progression in the TRAMP mouse model. The chemopreventive effects of ASC-J9 were demonstrated by early i.p. injection at 8 weeks old with continued treatment until 23 to 24 weeks old. The prostates (prostate tumors or precancerous lesions) were harvested and photographed (left panel), and the prostate mass weights were calculated (right panel). N = 6 mice per group. B: ASC-J9 treatment suppressed the growth of TRAMP tumor chunks s.c. implanted into SCID mice. After 4 weeks of vehicle or ASC-J9 injection, the s.c. tumors were harvested and photographed (top panel), and the tumor weights were calculated (bottom panel). N = 6 for each group. C: TRAMP prostate tumor growth was inhibited by ASC-J9 after subrenal capsule implantation in SCID mice. After 4 weeks of vehicle or ASC-J9 injection, tumors were harvested and photographed (left panel), and the tumor weights were determined (right panel). N = 3 for each group. D: ASC-J9 displayed chemopreventive effects in the Pten+/− mouse model. ASC-J9 was administrated to 6-month-old Pten+/− mice, and the dorsolateral prostates were harvested 2 months after injection. Histologic examination of 8-month-old Pten+/+ DMSO, Pten+/− DMSO, and Pten+/− ASC-J9–treated prostates were subjected to H&E staining (left panel). The arrows point to the high-grade PIN lesions. Quantitation of high-grade PIN lesions is provided in the right panel. N = 5 to 6 mice per group. Error bars = mean ± SEM. Scale bars: 200 μm (original magnification, ×100) and 50μm (original magnifcation, ×400).
Article Snippet: C: The
Techniques: In Vivo, Injection, Staining, Quantitation Assay